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“…10.7.8 The Genome Sequencer 454 FLX System -- 10.7.9 Illumina/Solexa Genome Analyzer -- 10.7.10 Transition Sequencing Techniques -- 10.7.11 Ion-Torrent's Semiconductor Sequencing -- 10.7.12 Helico's Genetic Analysis Platform -- 10.7.13 Third-Generation Sequencing Techniques -- 10.8 Conclusion -- Abbreviations -- Acknowledgement -- References -- 11 Bioinformatics in Cancer Detection -- 11.1 Introduction -- 11.2 The Era of Bioinformatics in Cancer -- 11.3 Aid in Cancer Research via NCI -- 11.4 Application of Big Data in Developing Precision Medicine -- 11.5 Historical Perspective and Development -- 11.6 Bioinformatics-Based Approaches in the Study of Cancer -- 11.6.1 SLAMS -- 11.6.2 Module Maps -- 11.6.3 COPA -- 11.7 Conclusion and Future Challenges -- References -- 12 Genomic Association of Polycystic Ovarian Syndrome: Single-Nucleotide Polymorphisms and Their Role in Disease Progression -- 12.1 Introduction -- 12.2 FSHR Gene -- 12.3 IL-10 Gene -- 12.4 IRS-1 Gene -- 12.5 PCR Primers Used -- 12.6 Statistical Analysis -- 12.7 Conclusion -- References -- 13 An Insight of Protein Structure Predictions Using Homology Modeling -- 13.1 Introduction -- 13.2 Homology Modeling Approach -- 13.2.1 Strategies for Homology Modeling -- 13.2.2 Procedure -- 13.3 Steps Involved in Homology Modeling -- 13.3.1 Template Identification -- 13.3.2 Sequence Alignment -- 13.3.3 Backbone Generation -- 13.3.4 Loop Modeling -- 13.3.5 Side Chain Modeling -- 13.3.6 Model Optimization -- 13.3.6.1 Model Validation -- 13.4 Tools Used for Homology Modeling -- 13.4.1 Robetta -- 13.4.2 M4T (Multiple Templates) -- 13.4.3 I-Tasser (Iterative Implementation of the Threading Assembly Refinement) -- 13.4.4 ModBase -- 13.4.5 Swiss Model -- 13.4.6 PHYRE2 (Protein Homology/Analogy Recognition Engine 2) -- 13.4.7 Modeller -- 13.4.8 Conclusion -- Acknowledgement -- References…”
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